Resveratrol Suppresses Prostate Cancer Development
Researchers from the University of Alabama at Birmingham have shown that prostate cancer-prone mice fed resveratrol experience significant protection against development of the disease.1 Found in red wine and some fruits and vegetables, resveratrol is a polyphenol antioxidant that has previously been shown to extend life span in various organisms.2,3 Investigators wondered if its reputed anticancer activities would extend to prostate cancer prevention
Special mice bred to develop prostate tumors were fed either resveratrol in ordinary chow, beginning at five weeks of age, or a control diet lacking the phytochemical.1 The animals were examined at 12 or 28 weeks old. Among mice that had received resveratrol in the diet, the incidence of prostate adenocarcinoma was reduced by 7.7-fold. Various biochemical and histological findings indicated that resveratrol suppresses prostate cancer development through a variety of mechanisms.
— Dale Kiefer
- Harper CE, Patel BB, Wang J, Arabshani A, Eltoum IA, Lamartiniere CA. Resveratrol suppresses prostate cancer progression in transgenic mice. Carcinogenesis. 2007 Sep;28(9):1946-53.
- Valenzano DR, Cellerino A. Resveratrol and the pharmacology of aging: a new vertebrate model to validate an old molecule. Cell Cycle. 2006 May;5(10):1027-32
- Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino CA. Resveratrol prolongs lifespan and retards the onset of age-related markers in short-lived vertebrate. Curr Biol. 2006 Feb 7;16(3):296-300
